J.Nutr.Biochem. Cancer Detect.Prev. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. You can find Dim supplements at vitamin stores or online at retailers. While many DIM supplements contain 100 mg-800 mg of DIM, some studies show that a daily dose of 30 mg DIM is enough for the average person–in actuality, the body may only absorb up to a 60 mg dose. In a separate study that explored the role of DIM in the reversal of high-grade prostatic intraepithelial neoplasia (PIN), it was found that the structural changes in the prostate among those men who took DIM declined. Kim, E. J., Park, H., Kim, J., and Park, J. H. 3,3'-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators. J.Nutr. Biochem.Pharmacol. Research also shows that DIM contains strong anticancer properties (x). Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. Cancer Res. While DIM does not directly mimic or replace estrogen, using it will promote an improved estrogen metabolism. At this time there is not enough scientific information to determine an appropriate range of doses for diindolylmethane. J.Nutr. Ali, S., Banerjee, S., Ahmad, A., El-Rayes, B. F., Philip, P. A., and Sarkar, F. H. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. View abstract. Potential Side Effects of DIM:⁣-Brain fog⁣-Dark urine⁣-Fatigue⁣-Headache⁣-May decrease estrogen levels⁣-Nausea⁣ ⁣ We cringe when we see people blinding supplementing DIM without proper testing, as while it can be life changing for some people, it can also cause a lot of harm if it’s not the right supplement for us. Smith, S., Sepkovic, D., Bradlow, H. L., and Auborn, K. J. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . 2020;41(10):1395-1401. Nature's Way DIM Plus is used for estrogen metabolism which is the breakdown of estrogen in the liver attempting to eradicate it. ... You can take the higher dosage if you have significant health concerns, but always be guided by the recommendations on the package. Another very popular supplement, DeFormula’s DIM has 100 mg of DIM per capsule. Br J Cancer. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. Xue, L., Firestone, G. L., and Bjeldanes, L. F. DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways. Available at: https://ntp-server.niehs.nih.gov. Cancer Epidemiol.Biomarkers Prev. Cancer Epidemiol.Biomarkers Prev. Rahman, K. W., Li, Y., Wang, Z., Sarkar, S. H., and Sarkar, F. H. Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells. Carcinogenesis 2002;23(8):1297-1305. Do I need to worry about taking too much DIM? View abstract. The appropriate amount for each individual … But are the possible benefits worth the risk? Early research shows that taking diindolylmethane daily for 3 months does not improve cancer status in women with cervical cancer. In preliminary research, some scientists have found that diindolylmeth… Nachshon-Kedmi, M., Yannai, S., Haj, A., and Fares, F. A. Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells. You can get your natural intake of diindolylmethane if you include these healthy foods in your diet (x): When taken correctly in the small amounts found in foods, diindolymethane is likely safe. This survey is being conducted by the WebMD marketing sciences department. Nutr Cancer 2004;50(2):161-167. 2001;131(12):3294-3302. View abstract. View abstract. Chen I, McDougal A, Wang F, Safe S. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. All rights reserved. Mol.Carcinog. Parkin, D. R. and Malejka-Giganti, D. Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3'-diindolylmethane and its parent compound indole-3-carbinol. DIM supplements is commonly taken in doses of 100 mg to 200 mg. No adverse effects have been reported from Diindolylmethane supplements … Addressing hormonal imbalance and the effects of it can be extremely frustrating. 500mg - 750mg is the starting dose … © 2005 - 2019 WebMD LLC. Consuming high doses of diindolylmethane have been as… It demonstrated antiproliferative effects in animal and cancer cell models .It was also shown to inhibit invasion of normal tissue by cancer cells, and to inhibit angiogenesis in cell culture models .DIM induces apoptosis in pancreatic cancer cells and enhances the effect of erlotinib . View abstract. Studies on … Aggarwal, B. Hsu, E. L., Chen, N., Westbrook, A., Wang, F., Zhang, R., Taylor, R. T., and Hankinson, O. CXCR4 and CXCL12 down-regulation: a novel mechanism for the chemoprotection of 3,3'-diindolylmethane for breast and ovarian cancers. View abstract. Researchers deem DIM Plus safe in low-dose, short-term supplement form for most consumers. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. A person’s age, health history and other conditions will determine the appropriate dosage. 2006;20(2):295-305. The appropriate dose of diindolylmethane depends on several factors such as the user's age, health, and several other conditions. J Nutr 2003;133(7 Suppl):2448S-2455S. 11 The trick is figuring out the conditions of these bio-actions. DIM supplements contain diindolymethane, which is found in cruciferous vegetables like broccoli and cabbage. In supplement form, DIM is frequently prescribed for survivors of breast, uterine and colorectal cancer. Prostate cancer. However, it’s best to take about 100 mg (1/16 tsp) or 200 mg (scant 1/8 tsp) once or twice daily. Biochem.Pharmacol. Vitamins and Supplements to Avoid with Hepatitis C. Quiz: What Do You Know About Vitamin B12 Deficiency? 1993;46(6):791-798. Carter, T. H., Liu, K., Ralph, W., Jr., Chen, D., Qi, M., Fan, S., Yuan, F., Rosen, E. M., and Auborn, K. J. Diindolylmethane alters gene expression in human keratinocytes in vitro. Placebo ( x ), Telang NT, Osborne MP hormonal acne ) in regulating gene expression of II... 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