The only thing that has ever killed Superman. Deadpool was his most heroic when he briefly served as an Avenger -- before a choice to follow the orders of Captain America during Secret Empire cost him everything. Not only that, but every time somebody kills you, you just come back immune to whatever killed you before. Well now it's payback time, because this time around, the heroes are beating down Deadpool. But that’s the beauty of Deadpool as he is very unpredictable, we know that he has stunning kill list on his name, and had killed the whole of Marvel universe in an alternate reality so Deadpool could beat Superman with ease. Where Superman refuses to kill, that is all Deadpool … One of the main reasons that the Merc with a Mouth is so lethal is because he’s dedicated to killing his targets. Even if Bane can't punch deadpool out he can still put him into a submission hold or something along those lines which would count as incapacitation. Superman is the most overpowered of ALL comic book hero's and as for Deadpool he isn't immortal he can die. But traditionally even Batman was still a hero who didn’t kill indiscriminately. The only way to kill you permanently is to destroy you entirely. Superman is the typical hero, and Batman is more the antihero type. Likewise, when it comes to comic books, there always has been a range of superheroes. "Dreadpool," the evil Deadpool from Deadpool Kills the Marvel Universe, is searching for new universes to depopulate and stumbles into the Post-Crisis DC Universe.. Dreadpool: has a healing factor that's cranked up beyond even Deadpool's typical standards. Marvel have just announced "The Death of Deadpool". Even Jesus can be seen as a kind of outlaw, in that He came into conflict with a corrupt legal system. ... Now, Deadpool can get drunk. This includes some notoriously hard to kill characters like the Hulk, Wolverine, Luke Cage, and the rest of the Avengers and the X-Men. During that comic's first arc, "If Looks Could Kill," the titular heroes are infected by the Facade Virus, a disease that allows victims to change their faces. I just don't think he has the intelligence to lay a good enough trap to beat and or kill Superman. We've already talked about the superheroes Deadpool has beaten, many of whom were courtesy of Deadpool's killing spree against the Marvel universe. Deadpool Annual #1 It’s kind of hard to call wrong place, wrong time in comics’ most superhero dense city, but such is the way of Deadpool’s run in with Thor. Supes looks at Deadpool and his Swords or Guns chuckles a bit then throws him into space. Marvel Comics has announced, via Nerdist, that they will be killing Deadpool in April's Deadpool #250, which will be the final issue of his ongoing series. 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